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About


The TARVA trial is a clinical trial for patients with ankle arthritis that are considering surgery. TARVA stands for Total Ankle Replacement Versus Arthrodesis.

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About


The TARVA trial is a clinical trial for patients with ankle arthritis that are considering surgery. TARVA stands for Total Ankle Replacement Versus Arthrodesis.

 

Introduction

The main surgical treatments for end-stage ankle arthritis are ankle arthrodesis or total ankle replacement (TAR). Approximately 3,000 patients with ankle arthritis undergo ankle arthrodesis or TAR in the NHS each year. Both treatments are available on the NHS, and both have been reported to have good results. Some studies suggest that TAR restores a more natural walking pattern than ankle fusion but other studies have suggested that the need for further surgery is higher with TAR than with fusion. Information on all TARs implanted in the NHS has been captured on the National Joint Registry since 2010, but no similar national registry exists for ankle fusion. There has never been a published randomized trial directly comparing the two procedures.

 
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Ankle Arthritis


Most ankle arthritis is as a result of what is known as "wear and tear" (or osteoarthritis). Other forms of ankle arthritis exist which can effect the ankle such as inflammatory arthritis, an example of which would be rheumatoid arthritis

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Ankle Arthritis


Most ankle arthritis is as a result of what is known as "wear and tear" (or osteoarthritis). Other forms of ankle arthritis exist which can effect the ankle such as inflammatory arthritis, an example of which would be rheumatoid arthritis

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Treatments


We will discuss the benefits and risks of both procedures and whether any additional procedures will be needed at the time of the operation.

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Treatments


We will discuss the benefits and risks of both procedures and whether any additional procedures will be needed at the time of the operation.

Ankle Replacement

Total ankle replacement is an operation to replace a worn-out ankle joint by resurfacing the ends of your tibia and…

Ankle Fusion

Ankle Fusion (Arthrodesis) Ankle fusion is an operation to convert a stiff painful joint into an even stiffer but painless…

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Trial Oversight


 

Ensuring Compliance, Patient Safety and Data Integrity.

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Trial Oversight


 

Ensuring Compliance, Patient Safety and Data Integrity.

Trial Steering Committee

Is responsible for oversight of the trial in order to safeguard the interests of trial patients. The TSC is comprised of a 75% majority of independent and lay members, as well as the Chief Investigator, representatives of Principal Investigators, a representative of the sponsor, the health economist and senior trial statistician. The committee provides advice to the Chief Investigator, UCL Comprehensive Clinical Trials Unit, the funder and sponsor on all aspects of the trial through its Independent Chair.  The remit of the TSC is to oversee study conduct and advise the TMG.

 

The Trial Management Group

Is responsible for the day-to-day management of the trial, including monitoring of all aspects of the conduct and progress of the trial, ensuring that the protocol is adhered to and taking appropriate action to safeguard participants and the quality of the trial itself.

 

Independent Data Monitoring Committee

Is the only oversight body that has access to un-blinded accumulating comparative data. The IDMC is responsible for safeguarding the interests of trial patients, monitoring the accumulating data and making recommendations to the TSC on whether the trial should continue as planned.

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Specialists


The TARVA study group includes many of the most experienced foot & ankle orthopaedic specialists in the UK. Each of the individuals listed below is a member of the TARVA publication group, and have contributed towards the TARVA protocol and research publications

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Specialists


The TARVA study group includes many of the most experienced foot & ankle orthopaedic specialists in the UK. Each of the individuals listed below is a member of the TARVA publication group, and have contributed towards the TARVA protocol and research publications

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Centres


The TARVA study is being carried out in 17 NHS hospitals across the UK.

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Centres


The TARVA study is being carried out in 17 NHS hospitals across the UK.

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Testimonials


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Testimonials


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Resources


A place to find helpful patient information

Ankle Arthritis Patient Information

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Resources


A place to find helpful patient information

Ankle Arthritis Patient Information

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News & Blogs


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Contact


Drop us a note, pick up the phone we'd love to hear from you.

 

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Contact


Drop us a note, pick up the phone we'd love to hear from you.

 

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